Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. doi: 10.1016/j.bmcl.2004.10.036.

Abstract

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ligands
  • Models, Molecular
  • Oxathiins / chemistry
  • Oxathiins / pharmacology*
  • Pyrrolidines / chemistry*
  • Receptors, Estrogen / drug effects*
  • Receptors, Estrogen / metabolism
  • Selective Estrogen Receptor Modulators / pharmacology*

Substances

  • Ligands
  • Oxathiins
  • Pyrrolidines
  • Receptors, Estrogen
  • Selective Estrogen Receptor Modulators
  • dihydrobenzoxathiin
  • pyrrolidine